Table 1 HIV-1 rate and spectrum of point mutations*.
From: The external domains of the HIV-1 envelope are a mutational cold spot
Replicate | env (2,598 nt) | int–vif–vpr (1,566 nt) | ||||
|---|---|---|---|---|---|---|
1 | 2 | 3 | 1 | 2 | 3 | |
G→A | 20 | 10 | 18 | 18 | 15 | 19 |
Other transitions | 10 | 3 | 3 | 10 | 4 | 9 |
Transversions | 8 | 4 | 17 | 6 | 6 | 8 |
Insertions | 3 | 4 | 2 | 0 | 3 | 2 |
Deletions | 0 | 0 | 2 | 1 | 1 | 0 |
Total mutations | 41 | 21 | 42 | 35 | 29 | 38 |
Bases sequenced | 246,281 | 222,208 | 248,935 | 75,168 | 75,168 | 76,734 |
Infection cycles | 4 | 4 | 4 | 6 | 6 | 6 |
Mutation rate (m/n/c) | 4.2 × 10−5 | 2.4 × 10−5 | 4.2 × 10−5 | 7.8 × 10−5 | 6.4 × 10−5 | 8.3 × 10−5 |
