Table 2 Multivariate Cox regression analysis of the five-CpG-based classifier with overall survival in the four sets.

From: A CpG-methylation-based assay to predict survival in clear cell renal cell carcinoma

Parameters

SYSU set

MCHC set

UTSW set

TCGA set

 

HR (95% CI)

P -value

HR (95% CI)

P -value

HR (95% CI)

P -value

HR (95% CI)

P -value

Age (younger than 60 years versus 60 years or older)

1.18 (0.66–2.11)

0.58

2.13 (1.36–3.33)

0.001

1.76 (0.98–3.14)

0.06

1.28 (0.81–2.02)

0.29

pT (T1/2 versus T3/4)

2.82 (1.42–5.56)

0.003

1.99 (1.20–3.31)

0.008

2.39 (1.27–4.50)

0.007

1.63 (1.01–2.63)

0.05

pN (N0 versus N1)

3.16 (1.37–7.28)

0.007

4.59 (2.39–8.83)

<0.001

2.01 (0.95–4.26)

0.07

—*

—*

M (M0 versus M1)

7.41 (1.97–27.89)

0.003

1.61 (0.60–4.27)

0.34

3.10 (1.46–6.57)

0.003

2.77 (1.78–4.31)

<0.001

Grade (G1/2 versus G3/4)

1.88 (0.97–3.66)

0.06

1.60 (1.01–2.56)

0.05

1.34 (0.69–2.60)

0.39

1.84 (1.07–3.19)

0.03

Tumour necrosis (absent versus present)

1.28 (0.96–1.71)

0.09

1.46 (1.17–1.83)

0.001

1.10 (0.81–1.50)

0.53

2.46 (1.48–4.09)

0.001

Five-CpG-based classifier (low versus high risk)

4.10 (2.05–8.19)

<0.001

3.73 (2.28–6.09)

<0.001

3.36 (1.78–6.34)

<0.001

1.80 (1.11–2.93)

0.02

  1. CI, confidence interval; HR, hazard ratio; MCHC, multiple clinical centres in China; SYSU, Sun Yat-sen University; TCGA, The Cancer Genome Atlas; UTSW, University of Texas Southwestern Medical Center at Dallas.
  2. Tumour size was not included in the multivariate analysis due to colinearity with pathologic T stage.
  3. *pN was not included in the multivariate analysis in TCGA set, because pN (N0 versus N1) was not a prognostic factor (P-value=0.21) in univariate Cox regression analysis and the nodal involvement status of 161 patients (54% of the total of 298 patients) was not available in this set.
Back to article page