Figure 7: POH1 expression is upregulated in human HCC tissues and correlates with E2F1 abundance.
From: POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation
(a) Immunoblotting analysis of POH1 and E2F1 expression in 10 pairs of HCCs and non-tumoral liver tissues. *Non-specific band. (b) POH1 immunochemical staining in 154 pairs of HCCs and non-tumoral tissues; representative photographs are presented. Scale bar, 100 μm. (c) The expression scores of POH1 and E2F1 for HCCs and non-tumoral liver tissues. Box-and-whisker plots are shown Boxes represent the upper and lower quartiles and median; whiskers show the data points that are neither lower than the first percentile nor greater than the 99th percentile. P values calculated by Wilcoxon signed-rank test are shown. (d) Correlation between POH1 scores and tumour stages in HCC samples. The scatter dot plot and the median with interquartile range are presented. P values from the multiple hypothesis testing (Holm–Sidak’s multiple comparisons test) are shown. (e) Case A: a representative specimen with high POH1 and E2F1 staining. Case B: a representative specimen with low POH1 and E2F1 staining. Scale bar, 100 μm. (f) Correlation between POH1 and E2F1 expression in HCC samples are shown (by Spearman correlation test). All P values are shown in the graphs.
