Figure 1: Comparative analysis and host origin association for S. Typhimurium genomes.
From: Allelic variation contributes to bacterial host specificity
(a) Functional distribution of core genes in 12 isolates; at left total numbers of SNPs with proportions of nonsynonymous substitutions (NS, blue) and synonymous substitutions (SS, red), and at right, the number of genes with (black) and without SNPs (grey). P-values for associations of sets of genes with SNPs and a given functional category (right-tailed Fisher exact test): *P<0.05; **P<0.01; ***P<0.001. (b) 3D scaling plot from a Random Forest proximity matrix of the SNPs from 15 adhesins (using the first 3 principal components) for human (light blue), bovine (green), equine (dark blue) and chicken (red) isolates; the analysis identified host-specific DNA signatures by separating subpopulations of isolates from the same host.
