Figure 2: AEP cleaves APP at N373 and N585 residues. | Nature Communications

Figure 2: AEP cleaves APP at N373 and N585 residues.

From: Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer’s disease

Figure 2

(a) Proteomic analysis of APP recombinant proteins processed by AEP. The detected peptide sequences indicate that N585 and N373 are the two main cleavage sites with the shed bands of molecular weight (MW) ∼130 and 80 kDa, respectively. (b) Proteomic analysis of APP fragments in AD brain. APP fragments cleaved after N585 was detected. (c) Processing of various mutant APP by AEP.

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