Figure 1: The crystal structure of Nek7 bound to Nek9.
From: Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
(a) Cartoon representation of Nek7 (teal, chain A) and stick representation of Nek9 810–825 (orange chain C). (b) Cartoon representation of Nek7 (pink, chain B) and Nek9 810–818 (orange, chain D). (c) Surface representation of Nek7 (teal, chain A) and stick representation of Nek9 810–825 (chain C). Carbon atoms in Nek9 are colour-coded according the results of the mutagenesis/co-precipitation data (Supplementary Fig. 1b,c): key binding residues (orange), non-essential residues (yellow) and untested residues (wheat). (d) Helical wheel plot of the Nek9 α-helix with residues colour-coded by chemical properties (inner circle: basic, blue; acidic, red; bulky hydrophobic, black; other, white) and contribution to Nek7 binding (outer circle, coloured as carbon atoms in c).
