Figure 4: Relationship between the conformation of residue 97 and the back-to-back interface.
From: Mechanistic basis of Nek7 activation through Nek9 binding and induced dimerization
(a,c,e) Active site viewed centred on residue 97. (b,d,f) View of the αC-β4 region that is involved in the back-to-back interface. In panels (d) and (f), the dimeric partner is shown as a thin ribbon with key residues shown as in sticks. The asterisk on Asn90* indicates that it belongs to the dimeric partner. Structures shown are: (a,d) Nek7WT alone (PDB code 2WQN, coloured grey); (b,e) Nek7Y97F, chain A (coloured teal); (c,f) Nek7 Y97F, chain B (coloured pink). (g) Schematic illustrations of the coupling between the conformation of residue 97 and the back-to-back interface.
