Figure 1: Auditory physiology.
From: KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing
(a) Superimposed auditory brainstem responses (ABR) waves of Kcnk5+/+ (black, n=1), Kcnk5+/− (blue, n=1) and Kcnk5−/− (magenta, n=1) mice to a 8-kHz tone pip delivered at three sound pressure levels (dB SPL). (b) Mean audiogram values (±s.e.m.) obtained from Kcnk5+/+ (black, n=6), Kcnk5+/− (blue, n=19), Kcnk5−/− (magenta, n=18), Kcnk3−/− (light green, n=9), Kcnk9−/− (dark green, n=4) and Kcnk3-9−/− (orange, n=12) mice. (c) ABR waves recorded from one Kcnk5+/+ (left panel) and one Kcnk5−/− (right panel) mice across postnatal days 14–21 as a function of tone-pip frequency (kHz) delivered at 80 dB SPL. Scale bars, 10 ms, 2 μV. (d) Individual values of the endocochlear potential recorded from the basal cochlear turn from Kcnk5+/+ (black, n=9), Kcnk5+/− (blue, n=13) and Kcnk5−/− (magenta, n=20) mice at different ages from postnatal day 19 to 90. (e) Values of endolymphatic K+ concentration at the basal turn of the cochlea in Kcnk5+/− (blue, n=5) and Kcnk5−/− (magenta, n=5) mice at postnatal day 19.
