Figure 6: GLB-12 regulates apoptosis via the p38/JNK MAPK pathways.
From: A redox signalling globin is essential for reproduction in Caenorhabditis elegans
(a) Acridine orange staining was used to visualize the increase in germline apoptosis following glb-12 RNAi. Scale bar: 10 μm. (b,c) glb-12 RNAi caused an increase in apoptosis in the WT and in mutants for CEP-1, EGL-1 and CED-13, but not in mutants for the p38/JNK MAPK pathways (n=5). Bars show average apoptotic corpses per animal in glb-12 RNAi treated animals, relative to control RNAi. The scheme shows the pathway associated with apoptosis (black) and upstream signalling pathways (blue), as well as a simplified version of the p38/JNK MAPK pathway. (d) glb-12 RNAi caused a further decrease in fecundity in mutants for the p38/JNK MAPK pathways (n=3). *P<0.05; **P<0.01 (two-sided Student t-test). Data are represented as mean±s.e.m.
