Figure 7: GLB-12 regulates apoptosis through redox signalling.
From: A redox signalling globin is essential for reproduction in Caenorhabditis elegans
(a) Ascorbic acid enhanced the glb-12 RNAi increase in apoptosis (n=6). (b,c) The GLB-12 mutants incapable of O2.− production and the cytosolic GLB-12 cannot rescue the apoptosis increase following glb-12 RNAi (n=5). (d,e) SOD-1 deletion and overexpression enhance and decrease the apoptosis increase following glb-12 RNAi, respectively (n=6). * in (d) indicates significant difference compared to the sod-1 mutant. (f) Introducing an intracellular PRDX-2 appears to mimic the effects seen for glb-12 RNAi in the mutant for SOD-1 (n=5). *P<0.05; **P<0.01 (two-sided Student t-test). Data are mean±s.e.m.
