Table 1 Association results of susceptibility loci associated with the atopic march.
From: Meta-analysis identifies seven susceptibility loci involved in the atopic march
SNP ID* | Chr | Position † | EA | AA | Set ‡ | AF | OR | 95% CI | P value | Genes |
|---|---|---|---|---|---|---|---|---|---|---|
rs12081541§ (i) | 1 | 150707990 | c | t | D | 0.091 | 1.61 | 1.41–1.89 | 8.5 × 10−11 | CRNN/LCE5A (FLG) |
rs17690965 (i) | 5 | 132058566 | c | g | D | 0.259 | 1.28 | 1.16–1.42 | 1.5 × 10−6 | IL4/KIF3A |
R1 | 0.271 | 1.18 | 1.05–1.32 | 4.8 × 10−3 | ||||||
Combined | 0.264 | 1.24 | 1.15–1.33 | 4.5 × 10−8 | ||||||
rs9357733 (i) | 6 | 52400095 | a | g | D | 0.815 | 1.29 | 1.13–1.46 | 9.5 × 10−5 | EFHC1 |
R1 | 0.807 | 1.27 | 1.11–1.45 | 5.1 × 10−4 | ||||||
R2 | 0.792 | 1.22 | 1.01–1.47 | 0.038 | ||||||
Combined | 0.808 | 1.27 | 1.17–1.38 | 2.1 × 10−8 | ||||||
rs479844 (g) | 11 | 65308533 | g | a | D | 0.558 | 1.28 | 1.16–1.41 | 3.6 × 10−7 | AP5B1/OVOL1 |
R1 | 0.563 | 1.22 | 1.25–1.54 | 2.0 × 10−4 | ||||||
Combined | 0.560 | 1.25 | 1.24–1.43 | 3.6 × 10−10 | ||||||
rs2155219 (i) | 11 | 75976842 | t | g | D | 0.481 | 1.28 | 1.17–1.41 | 1.5 × 10−7 | C11orf30/LRRC32 |
R1 | 0.494 | 1.39 | 1.25–1.54 | 1.2 × 10−9 | ||||||
Combined | 0.487 | 1.33 | 1.24–1.43 | 1.8 × 10−15 | ||||||
rs993226 (g) | 12 | 83410704 | g | t | D | 0.037 | 1.58 | 1.27–1.96 | 4.2 × 10−5 | SLC6A15/TMTC2 |
R1 | 0.033 | 1.59 | 1.23–2.04 | 4.0 × 10−4 | ||||||
R2 | 0.027 | 1.57 | 1.05–2.35 | 0.028 | ||||||
Combined | 0.034 | 1.58 | 1.35–1.84 | 5.3 × 10−9 | ||||||
rs10445308 (i) | 17 | 35191573 | c | t | D | 0.530 | 1.25 | 1.14–1.37 | 2.9 × 10−6 | IKZF3 |
R1 | 0.528 | 1.18 | 1.05–1.30 | 2.9 × 10−3 | ||||||
Combined | 0.529 | 1.22 | 1.14–1.30 | 4.7 × 10−8 |
