Table 1 Neutralization breadths and potencies of the five mAbs and convalescent sera.
Virus strain | Clades | IC50 (μg ml−1) | ID 50 dilutions | |||||
|---|---|---|---|---|---|---|---|---|
65C6 | 100F4 | 3C11 | AVFluIgG01 | AVFluIgG03 | SZ06 | AH06 | ||
A/Hong Kong/156/1997 | 0 | 0.005 | 0.05 | 0.018 | 0.066 | 0.008 | 3,202 | 664 |
A/Thailand/(KAN-1)/2004 | 1 | 0.029 | 0.067 | ND | 0.045 | ND | 6,231 | 1,957 |
A/Indonesia/5/2005 | 2.1.3.2 | 0.004 | 0.013 | 0.167 | 0.052 | 4.752 | 8,613 | 1,736 |
A/Turkey/65596/2006 | 2.2.1 | 0.002 | 0.004 | 0.118 | 0.006 | 1.861 | 8,598 | 2,562 |
A/common magpie/Hong Kong/5052/2007 | 2.3.2.1 | 0.034 | 0.066 | ND | 30.25 | ND | 225 | 160 |
A/Shenzhen/406H/2006 | 2.3.4 | 0.02 | 0.052 | 2.631 | 0.012 | 0.002 | 7,225 | 2,681 |
A/chicken/Guangxi/12/2004 | 2.4 | 0.005 | 0.015 | 6.85 | 12.667 | ND | 2,527 | 2,630 |
A/chicken/Korea/es/2003 | 2.5 | 0.005 | 0.016 | 1.047 | 0.016 | ND | 4,270 | 5,010 |
A/silky chicken/Hong Kong/SF189/2001 | 3 | 0.011 | 0.022 | 5.183 | 0.008 | 0.069 | 13,394 | 7,800 |
A/goose/Guiyang/337/2006 | 4 | 0.025 | 0.019 | ND | 5.556 | ND | 912 | 307 |
A/duck/Guangxi/1378/2004 | 5 | 0.005 | 0.021 | 0.379 | 0.019 | 0.009 | 16,932 | 16,329 |
A/blackbird/Hunan/1/2004 | 6 | 0.007 | 0.033 | 29.422 | 0.015 | 0.004 | 3,975 | 10,537 |
A/Beijing/01/2003 | 7 | 0.006 | 0.037 | 0.14 | 0.008 | 0.003 | 8,237 | 7,491 |
A/Chicken/Vietnam/NCVD-03/08 | 7.1 | ND | ND | ND | ND | 0.069 | 2,235 | 1,392 |
A/Chicken/Vietnam /NCVD-16/08 | 7.1 | ND | ND | ND | ND | 0.03 | 3,022 | 951 |
A/chicken/Henan/16/2004 | 8 | 0.014 | 0.036 | 11.257 | 0.026 | ND | 3,447 | 25,381 |
A/goose/Shantou/1621/2005 | 9 | 0.007 | 0.011 | 62.192 | 0.002 | 0.018 | 12,768 | 8,681 |
VSVG | ND | ND | ND | ND | ND | ND | ND | |
Average | 0.012 | 0.031 | 9.950 | 3.250 | 0.620 | 6,224 | 5,663 | |
s.d. | 0.010 | 0.020 | 18.474 | 8.229 | 1.477 | 4,711 | 6,732 | |
