Figure 3: Binding of sialylated receptor analogues to EV-D68 displaces the pocket factor.
From: Sialic acid-dependent cell entry of human enterovirus D68
(a) Superimposition of the amino acids lining the VP1 hydrophobic pocket in the native structure (light grey) and the receptor bound complex (green). The pocket factor in the native structure is coloured grey. (b) Two protomers of the EV-D68 capsid are represented as Cα backbones with VP1, VP2 and VP3 coloured blue, green and red, respectively. The pocket factor (native structure) and the receptor analogue (receptor bound complex) are coloured grey and cyan, respectively. (c) The sialic acid moiety (Neu5Ac) (cyan carbon atoms) interacts with surrounding amino acids (green carbon atoms). A water molecule is represented by a red sphere. Dash lines indicate polar interactions. Oxygen, nitrogen and sulfur atoms in (a,c) are colored red, dark blue and yellow, respectively.
