Figure 6: APP/PS1/TRPC6 mice showed improvement in spatial learning ability at 11 months. | Nature Communications

Figure 6: APP/PS1/TRPC6 mice showed improvement in spatial learning ability at 11 months.

From: TRPC6 specifically interacts with APP to inhibit its cleavage by γ-secretase and reduce Aβ production

Figure 6

(a) Representative images of Golgi staining of hippocampal CA1 neurons in the four groups of mice at 11 month. Scale bar, 5 μm. (b) Quantification of spine number per 10 μm of dendrite (n=40 neurons from 3–5 mice). (c) Cumulative probability analysis of the spine density shown in b. (d) Escape latency of the four groups of mice at 11 months in the training session of Morris water maze (n=15–19). (e) Platform crossing number of the mice at 11 month in the probe session of Morris water maze (n=14–19). Data were presented as means±s.e.m. One way ANOVA with Newman–Keuls post hoc test was performed for spine quantification and repeated measures and multivariate analysis in general linear model with LSD post hoc test was performed for behavioural study. *P<0.05, **P<0.01, ***P<0.001 versus WT or APP/PS1.

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