Figure 6: Chronic administration of the G-protein-biased agonist improves hepatic steatosis in DIO mice.
From: Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects
(a) Representative microscopy images of liver tissue from DIO mice following daily subcutaneous injections of saline (control), Ex4 or P5 and (b) lipid droplet number per HPF. Section were stained with Oil Red O to investigate the presence of lipids in the liver (n=4). Scale bar, 100 μm. (c) Liver triglyceride content normalized with liver weight and (d) liver weight in DIO mice following daily subcutaneous injections of saline (control), Ex4 or P5. (e) Effect of P5 or Ex4 on plasma on alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (n=8). Data are mean±s.e.m. Statistic by two-tailed t-test: *P<0.05; **P<0.01, comparing saline to peptide injection.
