Figure 7: Schematic depicting the identification and characterization of a novel GLP-1R-biased agonist. | Nature Communications

Figure 7: Schematic depicting the identification and characterization of a novel GLP-1R-biased agonist.

From: Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

Figure 7

Using an autocrine-based system coupled to FACS, we screened large, diverse, combinatorial peptide libraries and identified P5, a potent and selective G-protein-biased GLP-1R agonist. P5 displayed a decreased insulinotropic effect, yet significantly improved glucose tolerance and insulin responsiveness by promoting white adipocyte tissue hyperplasia.

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