Figure 6: Infection with Rv1988::M. smegmatis represses specific host genes. | Nature Communications

Figure 6: Infection with Rv1988::M. smegmatis represses specific host genes.

From: Mycobacteria modulate host epigenetic machinery by Rv1988 methylation of a non-tail arginine of histone H3

Figure 6

(a) Expression levels of the indicated genes measured by real-time qRT-PCR in THP1 macrophages infected with M. smegmatis expressing Rv1988 (black bars, Rv1988) or GFP::M. smegmatis (white bars, GFP). Levels were normalized against GAPDH. ncRNA: lincRNA ENSG00000250584. (b–f) Epigenetic modifications associated with the gene promoters. (b) Rv1988 binding; (c) dimethyl arginine; (d) H3K9me3; (e) H3K27me3; (f) H3K4me3. Region (b,c) were present within the intron of CDC42BPB and lincRNA ENSG00000250584, respectively. The error bars represent s.d. Student’s t-test, *P<0.05.

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