Figure 2: Copy-number variation analysis.
From: Exome sequencing of osteosarcoma reveals mutation signatures reminiscent of BRCA deficiency
(a) Copy-number profile of 123 OS genomes. (b) Significantly over-represented copy-number alterations. The most important over-represented SCNA loci are highlighted. Blue, gains; red, losses. (c) The number of copy-number alterations fulfilling specific criteria of a BRCA-like phenotype shown for each tumour (threshold line in red). (d) Homologous recombination deficiency (HRD) score shown for each tumour. The threshold for considering a tumour to be BRCA deficient was set to 15 (red dashed line).
