Figure 9: ODT is faster in GABRB3ΔGCL mice when challenged with more difficult discrimination tasks.
From: Disinhibition of olfactory bulb granule cells accelerates odour discrimination in mice
(a) Learning curves. Cineol and eugenol (CvE) were first used for task habituation. Afterwards, test odours, AA and EB (AAvEB) and their binary mixture in a 60:40 ratio (6/4v4/6) were used in progressively smaller concentrations to generate discrimination tasks of increasing difficulty. No differences in learning performance were observed between control (n=8) and GABRB3ΔGCL (n=8) mice for the different odour concentrations tested (mean±s.e.m.; ANOVA; P>0.05). The coloured bars (simple odours light blue and binary mixtures light green) depict the trials used for the determination of odour discrimination times. Because mice were unable to reach a high performance level (>90%) in the last dilution tested, the discrimination time for this concentration was not determined. (b) Odour discrimination times of the stimuli tested in a. All GABRB3ΔGCL (n=8) mice exhibited significantly faster discrimination times than control (n=8) mice. Simple odours: control 289±9 ms, GABRB3ΔGCL 250±15 ms, *P<0.05; 1% 6/4v4/6: control 335±9 ms, GABRB3ΔGCL 272±26 ms, *P=0.05; 0.1% 6/4v4/6: control 345±16 ms, GABRB3ΔGCL 304±8 ms, *P<0.05; 0.001% 6/4v4/6: control 390.0±16 ms, GABRB3ΔGCL 336±18 ms, *P<0.05; mean±s.e.m. All pairs of data sets were tested for significance using the t-test.
