Figure 8: Increased iNOS and p53 in Alexander disease patients.
From: Nitric oxide mediates glial-induced neurodegeneration in Alexander disease
(a) Quantification of iNOS protein levels reveals an increase in Alexander disease patients. *P=0.0042, t=2.326, df=8; unpaired t-test, n=5 for both ctrl and AxD. (b) Double-label immunofluorescence shows activation of p53 in astrocytes of Alexander disease patient (arrows), but not in control (arrowheads). Images were taken from the grey matter in frontal cortex. GFAP labels astrocytes. 4,6-Diamidino-2-phenylindole (DAPI) marks nuclei. Scale bar, 10 μm.
