Table 2 Rates of fracture in ADOPT.

From: Erratum: The effect of thiazolidinediones on BMD and osteoporosis

Patients with fracture

Number of patients (%)

 

Rosiglitazone

Metformin

Glyburide

Men

32(4.0)

29(3.4)

28(3.4)

Women

60(9.3)

30(5.1)a

21(3.5)a

Lower limb

36(5.6)

18(3.1)b

8(1.3)a

Upper limb

22(3.4

10(1.7)

9(1.5)b

Spinal

1(0.2)

1(0.2)

1(0.2)

  1. aP <0.01 for the comparison with rosiglitazone (unadjusted, contingency χ2 test).
  2. bP <0.05 for the comparison with rosiglitazone (unadjusted, contingency χ2 test). Abbreviation: ADOPT, A Diabetes Outcome Progression Trial. Permission obtained from Massachusetts Medical Society © Kahn SE et al. (2006) N Engl J Med 355: 2427–2443.
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