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IL-18 is involved in systemic JIA, but not in oligoarticular or polyarticular forms

Nature Clinical Practice Rheumatology volume 3, page 594 (2007)Cite this article

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Jelušić M et al. (2007) Interleukin-18 as a mediator of systemic juvenile idiopathic arthritis. Clin Rheumatol 26: 1332–1334

Juvenile idiopathic arthritis (JIA) is associated with abnormal production of cytokines. Interleukin (IL)-18 levels are elevated in children with systemic JIA and this cytokine is known to mediate articular damage in patients with rheumatoid arthritis. New data indicates that IL-18 is not involved in the pathogenesis of oligoarticular or polyarticular JIA, but could be a good therapeutic target for systemic JIA.

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IL-18 is involved in systemic JIA, but not in oligoarticular or polyarticular forms. Nat Rev Rheumatol 3, 594 (2007). https://doi.org/10.1038/ncprheum0602

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