Abstract
AN interaction between acetylcholine and noradrenaline has been suggested to occur in the autonomic nervous system1,2. No direct evidence of neurotransmitter interaction involving noradrenaline and the synthesis and metabolism of acetylcholine has been reported so far in the central nervous system. Noradrenaline and acetylcholine applied to structures in the central nervous system, including the ventricles, have been shown to induce eating and drinking behaviour respectively in rats satiated with food and water and to increase food and water intake in deprived rats. Conversely, acetylcholine blocks food intake and noradrenaline blocks water intake.
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SINGER, G., HO, A. & GERSHON, S. Changes in Activity of Choline Acetylase in Central Nervous System of Rat after Intraventricular Administration of Noradrenaline. Nature New Biology 230, 152–153 (1971). https://doi.org/10.1038/newbio230152b0
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DOI: https://doi.org/10.1038/newbio230152b0
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