Abstract
NORADRENALINE increases the intracellular concentration of adenosine 3′,5′-monophosphate (cyclic AMP)1,2 which, in turn, enhances glycogenosis3 and lipolysis4,5 in adipose tissue by increasing Phosphorylase and lipase activities. Prostaglandin E1 (PGE1) antagonizes the induced increases in Phosphorylase activity6,7 and glycerol release in human adipose tissues8,9 and isolated adipocytes7. The finding that the stimulatory effects of the cyclic AMP analogue N6—O2 dibutyryl cyclic AMP, which mimics the hormonal effect of noradrenaline in human fat cells, are not blocked by PGE17 suggests that noradrenaline and PGE1 alter fat cell metabolism by acting on the adenyl cyclase system10. Whether noradrenaline and PGE1 alter concentrations of cyclic AMP in human fat cells, however, has not been reported.
This is a preview of subscription content, access via your institution
Access options
References
Sutherland, E. W., and Robinson, G. A., Pharmacol. Rev., 18, 145 (1966).
Butcher, R. W., and Baird, C. E., J. Biol. Chem., 248, 1713 (1968).
Vaughan, M., J. Biol. Chem., 235, 3049 (1960).
Rizack, M. A., in Handbook of Physiology, Section 5 (edit. by Renold, A. E., and Cahill, jun., G. F.), 309 (Williams and Wilkins, Baltimore, 1965).
Weiss, B., Davis, J. I., and Brodie, B. B., Biochem. Pharmacol., 15, 1553 (1966).
Steinberg, D., and Vaughan, M., J. Clin. Invest., 43, 1553 (1964).
Moskowitz, J., and Fain, J. N., J. Clin. Invest., 48, 1802 (1969).
Carlson, L. A., and Hallbert, D., J. Lab. Clin. Med., 71, 368 (1968).
Bergstrom, S., and Carlson, L. A., Acta Physiol. Scand., 63, 195 (1965).
Fain, J. N., Endocrinology, 82, 325 (1968).
Rodbell, M., J. Biol. Chem., 239, 375 (1964).
Kuo, J. F., and Renzo, E. C., J. Biol. Chem., 244, 2252 (1969).
Krishna, G., Weiss, B., and Brodie, B. B., J. Pharmacol. Exp. Ther., 163, 379 (1968).
Forn, J., Schönhöfer, P. S., Skidmore, I. F., and Krishna, G., Biochim. Biophys. Acta (in the press).
Moskowitz, J., and Fain, J. N., J. Biol. Chem., 245, 1101 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
MOSKOWTTZ, J., HARWOOD, J., FORN, J. et al. Effect of Noradrenaline and Prostaglandin E1 on Adenosine 3′,5′;-Monophosphate Formation in Isolated Pericardial Fat Cells of Man. Nature New Biology 230, 214–215 (1971). https://doi.org/10.1038/newbio230214a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/newbio230214a0
