Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Role of the Liver in Inflammation

Abstract

INFLAMMATION leads to the appearance in plasma and inflammatory exudates of a protein with anti-inflammatory properties1–4. The greatest concentration of this anti-inflammatory protein (AIP) occurs relatively late after injury2, which suggests that it plays a role in the later stages of the inflammatory reaction and during healing. The synthesis of the protein is shown here to be similar to that of most other plasma proteins in that it occurs in the liver, which raises the question of the extent to which inflammation is influenced or controlled by the rates of synthesis of plasma proteins.

This is a preview of subscription content, access via your institution

Access options

References

  1. Billingham, M. E. J., Robinson, B. V., and Robson, J. M., Brit. J. Pharmacol., 35, 543 (1969).

    Article  CAS  Google Scholar 

  2. Billingham, M. E. J., Robinson, B. V., and Robson, J. M., Brit. Med. J., 2, 93 (1969).

    Article  CAS  Google Scholar 

  3. Gaugas, J. M., Billingham, M. E. J., and Rees, R. W., Amer. Rev. Resp. Dis., 101, 432 (1970).

    CAS  PubMed  Google Scholar 

  4. Billingham, M. E. J., Robinson, B. V., and Gaugas, J. M., Nature, 227, 276 (1970).

    Article  CAS  Google Scholar 

  5. Winter, C. A., Risley, E. A., and Nuss, G. W., Proc. Soc. Exp. Biol. Med., 111, 544 (1962).

    Article  CAS  Google Scholar 

  6. Beard, N. S., Armentrout, S. A., and Weisberger, A. S., Pharm. Revs., 21, 213 (1969).

    CAS  Google Scholar 

  7. Gordon, A. H., and Darcy, D. A., Brit. J. Exp. Pathol., 48, 81 (1967).

    CAS  Google Scholar 

  8. Robinson, B. V., and Robson, J. M., Brit. J. Pharmacol., 26, 372 (1966).

    CAS  PubMed  Google Scholar 

  9. DiPasquale, G., Girerd, R. J., Beach, V. L., and Steinetz, B. G., Amer. J. Physiol., 205, 1080 (1963).

    Article  CAS  Google Scholar 

  10. Glenn, E. M., Bowman, B. J., and Koslowske, T. C., in Chemical Biology of Inflammation, 27, Biochem. Pharm. Suppl. (March 1968).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

BILLINGHAM, M., GORDON, A. & ROBINSON, B. Role of the Liver in Inflammation. Nature New Biology 231, 26–27 (1971). https://doi.org/10.1038/newbio231026a0

Download citation

  • Received:

  • Issue date:

  • DOI: https://doi.org/10.1038/newbio231026a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing