Abstract
Globin mRNA from rabbit reticulocytes can be translated equally well by human ribosomes from thalassaemic and normal reticulocytes. This implies that the defect in β-thalassaemia is not in the ability of ribosomes to translate mRNA but is probably in the mRNA itself.
This is a preview of subscription content, access via your institution
Access options
Similar content being viewed by others
References
Baglioni, C., in Molecular Genetics, Part 1 (edit. by Taylor, J. H.), 405 (Academic Press, London and New York, 1963).
Heywood, D., Karon, M., and Weissman, S., J. Lab. Clin. Med., 66, 476 (1965).
Weatherall, D. J., Clegg, J. B., and Naughton, M. A., Nature, 208, 1061 (1965).
Bank, A., Braverman, A. S., O'Donnell, J. V., and Marks, P. A., Blood, 31, 226 (1968).
Gilbert, J. M., Thornton, A. G., Nienhuis, A. W., and Anderson, W. F., Proc. US Nat. Acad. Sci., 67, 1854 (1970).
Bank, A., and Marks, P. A., J. Clin. Invest., 45, 330 (1966).
Evans, M. J., and Lingrel, J. B., Biochemistry, 8, 3000 (1969).
Noll, H., in Techniques in Protein Biosynthesis, 2 (edit. by Campbell, P. N., and Sargent, J. R.), 101 (Academic Press, London and New York, 1969).
McCarty, K. S., Stafford, D., and Brown, O., Anal. Biochem., 24, 314 (1968)
Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol., 19, 91 (1966)
Kan, Y. W., Schwartz, E., and Nathan, D. G., J. Clin. Invest., 47, 2515 (1968).
Dintzis, H. M., Proc. US Nat. Acad. Sci., 47, 247 (1961).
Gilbert, J. M., and Anderson, W. F., J. Biol. Chem., 245, 2342 (1970).
Chantrenne, H., Burny, A., and Marbaix, G., in Progress in Nucleic Acid Research and Molecular Biology, 7 (edit. by Davidson, J. N., and Cohn, W. E.), 173 (Academic Press, London and New York, 1967).
Holder, J. W., and Lingrel, J. B., Biochim. Biophys. Acta, 204, 210 (1970).
Kruh, J., Schapira, G., Lareau, J., and Dreyfus, J. C., Biochim. Biophys. Acta, 87, 669 (1964).
Drach, J. C., and Lingrel, J. B., Biochim. Biophys. Acta, 123, 345 (1966).
Kruh, J., Dreyfus, J. C., and Schapira, G., Biochim. Biophys. Acta, 114, 371 (1966).
Grossbard, L., Banks, J., and Marks, P. A., Arch. Biochem. Biophys., 125, 580 (1968).
Schapira, G., Dreyfus, J. C., and Maleknia, N., Biochem. Biophys. Res. Commun., 32, 558 (1968).
Laycock, D. G., and Hunt, J. A., Nature, 221, 1118 (1969).
Heywood, S. M., Proc. US Nat. Acad. Sci., 67, 1782 (1970).
Lockard, R. E., and Lingrel, J. B., Biochem. Biophys. Res. Commun., 37, 204 (1969).
Prichard, P. M., Gilbert, J. M., Shafritz, D. A., and Anderson, W. F., Nature, 226, 511 (1970).
Shafritz, D. A., and Anderson, W. F., J. Biol. Chem., 245, 5553 (1970).
Shafritz, D. A., and Anderson, W. F., Nature, 227, 918 (1970).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
NIENHUIS, A., LAYCOCK, D. & ANDERSON, W. Translation of Rabbit Haemoglobin Messenger RNA by Thalassaemic and Non-thalassaemic Ribosomes. Nature New Biology 231, 205–208 (1971). https://doi.org/10.1038/newbio231205a0
Received:
Issue date:
DOI: https://doi.org/10.1038/newbio231205a0
This article is cited by
-
Regulatory interactions involving two hemoglobin loci of Chironomus
Biochemical Genetics (1973)
