Abstract
DURING our work on Chemotaxis of leucocytes, we have consistently noted that coagulation of normal blood from various species leads to the generation or liberation of leuco-tactic factors. Chromatographic purification of normal rabbit sera has led to the isolation of a low molecular weight neutrophil specific factor and a high molecular weight macrophage specific factor1. The origin and mechanism of formation of these serum leucotactic agents remained unclear. In view of the known accumulation of leucocytes, especially neutrophils, around thrombi, and the occurrence of coagulation in immunologically and nonimmunologically induced inflammatory processes, we have investigated the link between coagulation and Chemotaxis.
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References
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STECHER, V., SORKIN, E. & RYAN, G. Relation between Blood Coagulation and Chemotaxis of Leucocytes. Nature New Biology 233, 95–96 (1971). https://doi.org/10.1038/newbio233095a0
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DOI: https://doi.org/10.1038/newbio233095a0
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