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Role of Energized States of (Na+ + K+-ATPase in the Sodium Pump

Nature New Biology volume 233, pages 171–172 (1971)Cite this article

Abstract

IN an earlier paper1 we have presented a model for a sodium pump based on the operation of the adenosine triphosphatase component of membranes which is sensitive to ouabain and is activated by sodium and potassium; that is (Na++K+)-ATPase. We attempted to correlate the biochemical properties of this enzyme system as they were then known with the essential properties of Na+ transport systems. The model suggested further experiments which could clarify the role of (Na+ + K +)-ATPase in ion transport, and some experimental evidence is now available for the stoichiometry of ouabain binding to isolated enzyme preparations2,3 although differences in the experimental techniques which have been used make the data equivocal.

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Authors and Affiliations

  1. Department of Pharmacology, University of Alberta, Edmonton, 7, Alberta

    J. S. CHARNOCK & D. A. COOK

  2. Department of Social Medicine, university of Birmingham,

    L. J. OPIT

Authors
  1. J. S. CHARNOCK
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  2. D. A. COOK
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  3. L. J. OPIT
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CHARNOCK, J., COOK, D. & OPIT, L. Role of Energized States of (Na+ + K+-ATPase in the Sodium Pump. Nature New Biology 233, 171–172 (1971). https://doi.org/10.1038/newbio233171a0

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  • DOI: https://doi.org/10.1038/newbio233171a0

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