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Excitation of Supraoptic Neurosecretory Cells by Angiotensin II

Nature New Biology volume 233, pages 172–174 (1971)Cite this article

Abstract

ANGIOTENSIN II, a circulating peptide which regulates electrolyte balance by controlling the adrenal release of aldosterone, may also act on the central nervous system. The reported central effects include elevations of blood pressure1–6, drinking behaviour7–11, adrenocorticotrophic hormone release12,13 and antidiuretic hormone (ADH) release5,14,15. The evidence for ADH release from the supraoptico-neurohypophysial system is based on studies involving the parenteral and intraventricular administration of angiotensin II. These routes of administration make an exact localization of the releasing action impossible and therefore we have attempted to locate the site by applying angiotensin II directly to individual supraoptic neurosecretory cells. We now report that angiotensin II increases the discharge rate of these and other neurones in the supraoptic nucleus.

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Author notes

  1. JEFFERY L. BARKER

    Present address: Electroencephalography Branch, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Bethesda, Maryland, 20014

Authors and Affiliations

  1. Laboratory of Neuropharmacology, National Institute of Mental Health, Saint Elizabeth's Hospital, Washington DC, 20032

    ROGER A. NICOLL & JEFFERY L. BARKER

Authors
  1. ROGER A. NICOLL
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  2. JEFFERY L. BARKER
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NICOLL, R., BARKER, J. Excitation of Supraoptic Neurosecretory Cells by Angiotensin II. Nature New Biology 233, 172–174 (1971). https://doi.org/10.1038/newbio233172a0

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