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Isotypes in Human Immunoglobulin λ-Chains

Nature New Biology volume 234, pages 58–61 (1971)Cite this article

Abstract

IMMUNOGLOBULIN polypeptide chains consist of a variable N-terminal region and a constant C-terminal part1. The variability of the N-terminal part is due to multiple amino-acid exchanges and deletions, which can be arranged into chemically distinct subgroups2–9. The C-terminal part is characterized by single amino-acid substitutions in an otherwise constant, yet chain type specific, sequence1,10–12.

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References

  1. Hilschmann, N., and Craig, L. C., Proc. US Nat. Acad. Sci., 53, 1403 (1965).

    Article  CAS  Google Scholar 

  2. Langer, B., Steinmetz-Kayne, M., and Hilschmann, N., Z. Physiol. Chem., 349, 945 (1968).

    CAS  Google Scholar 

  3. Hilschmann, N., Z. Physiol. Chem., 348, 1718 (1967).

    Article  CAS  Google Scholar 

  4. Niall, H. D., and Edman, P., Nature, 216, 262 (1967).

    Article  CAS  Google Scholar 

  5. Milstein, C., Nature, 216, 330 (1967).

    Article  CAS  Google Scholar 

  6. Hood, L., and Ein, D., Nature, 220, 764 (1968).

    Article  CAS  Google Scholar 

  7. Ponstingl, H., Schwarz, J., Reichel, W., and Hilschmann, N., Z. Physiol. Chem., 351, 1591 (1970).

    CAS  Google Scholar 

  8. Watanabe, S., and Hilschmann, N., Z. Physiol. Chem., 351, 1291 (1970).

    CAS  Google Scholar 

  9. Schiechl, H., and Hilschmann, N., Z. Physiol. Chem. (in the press).

  10. Ponstingl, H., Hess, M., Langer, B., Steinmetz-Kayne, M., and Hilschmann, N., Z. Physiol. Chem., 348, 1213 (1967).

    CAS  Google Scholar 

  11. Apella, E., and Ein, D., Proc. US Nat. Acad. Sci., 57, 1449 (1967).

    Article  Google Scholar 

  12. Milstein, C., Biochem. J., 104, 28c (1967).

    Article  CAS  Google Scholar 

  13. Hilschmann, N., Barnikol, H. U., Hess, M., Langer, B., Ponstingl, H., Steinmetz-Kayne, M., Suter, L., and Watanabe, S., Proc. Fifth FEBS Meeting (edit. by Franek, F., and Shugar, D.), 57 (Academic Press, New York, 1968).

    Google Scholar 

  14. Hilschmann, N., Ponstingl, H., Baczko, K., Braun, D. G., Hess, M., Suter, L., Barnikol, H. U., and Watanabe, S., Proc. Seventeenth Coll. Protides Biol. Fluids (edit. by Peeters, H.), 53 (Academic Press, New York, 1969).

    Google Scholar 

  15. Hilschmann, N., Naturwissenschaften, 56, 195 (1969).

    Article  CAS  Google Scholar 

  16. Hilschmann, N., Barnikol, H. U., Hess, M., Langer, B., Ponstingl, H., Steinmetz-Kayne, M., Suter, L., and Watanabe, S., Current Problems in Immunology (edit. by Westphal, O., Bock, H. E., and Grundmann, E.), 69 (Springer, Berlin, 1969).

    Google Scholar 

  17. Hood, L., and Talmage, D. W., Science, 168, 325 (1970).

    Article  CAS  Google Scholar 

  18. Edelman, G. M., and Gall, W. E., Ann. Rev. Biochem., 38, 415 (1969).

    Article  CAS  Google Scholar 

  19. Cold Spring Harbor Symp. Quant. Biol., 32 (1967).

  20. Ropartz, C., Lenoir, J., and Rivat, L., Nature, 189, 586 (1961).

    Article  CAS  Google Scholar 

  21. Steinberg, A. G., Wilson, J. A., and Lanset, S., Vox Sang., 7, 151 (1962).

    Article  CAS  Google Scholar 

  22. Baglioni, C., Alescio-Zonta, L., Cioli, D., and Carbonara, A., Science, 152, 1519 (1966).

    Article  Google Scholar 

  23. Hilschmann, N., Proc. Eleventh Congr. Int. Soc. Blood Transf., Sydney 1966; Bibl. Haematol., 29, Part 2 (edit. by Holländer, L. P.), 501 (Karger, Basle, New York, 1968).

    Google Scholar 

  24. Milstein, C., Nature, 209, 370 (1966).

    Article  CAS  Google Scholar 

  25. Grubb, R., The Genetic Marker of Human Immunoglobulins, 52 (Springer, New York, 1970).

    Book  Google Scholar 

  26. Vyas, G. N., and Fudenberg, H. H., Proc. US Nat. Acad. Sci., 64, 1211 (1970).

    Article  Google Scholar 

  27. Kunkel, H. G., Smith, W. K., Joslin, F. G., Natvig, J. B., and Litwin, S. D., Nature, 223, 1247 (1969).

    Article  CAS  Google Scholar 

  28. Ein, D., and Fahey, J. L., Science, 156, 947 (1967).

    Article  CAS  Google Scholar 

  29. Ein, D., Proc. US Nat. Acad. Sci., 60, 982 (1968).

    Article  CAS  Google Scholar 

  30. Ponstingl, H., Hess, M., and Hilschmann, N., Z. Physiol. Chem., 349, 867 (1968).

    CAS  Google Scholar 

  31. Ponstingl, H., Hess, M., and Hilschmann, N., Z. Physiol. Chem., 352, 195, 203, 247 (1971).

    Article  CAS  Google Scholar 

  32. Hess, M., Ponstingl, H., and Hilschmann, N., Z. Physiol. Chem., 352, 214, 231 (1971).

    CAS  Google Scholar 

  33. Hess, M., and Hilschmann, N., Z. Physiol. Chem., 351, 67 (1970).

    Article  CAS  Google Scholar 

  34. Hess, M., and Hilschmann, N., Z. Physiol. Chem., 352, 657 (1971).

    Article  CAS  Google Scholar 

  35. Baczko, K., Braun, D. G., Hess, M., and Hilschmann, N., Z. Physiol. Chem., 351, 763 (1970).

    CAS  Google Scholar 

  36. Garver, F., and Hilschmann, N., FEBS Lett., 16, 128 (1971).

    Article  CAS  Google Scholar 

  37. Milstein, C., Milstein, C. P., and Jarvis, J. M., J. Mol. Biol., 46, 599 (1969).

    Article  CAS  Google Scholar 

  38. Ein, D., and Hood, L., Fed. Proc., 127, 559 (1968).

    Google Scholar 

  39. Rivat, L., Rivat, C., Ropartz, C., and Hess, M., Europ. J. Clin. Biol. Res. (in the press).

  40. Hilschmann, N., Ponstingl, H., Schwarz, J., Reichel, W., Baczko, K., Braun, D. G., Hess, M., Watanabe, S., Suter, L., and Barnikol, H. U., Thirteenth Intern. Cong. Haematol., 149 (Lehmanns, Munich, 1970).

    Google Scholar 

  41. Wikler, M., Köhler, H., Shinoda, T., and Putnam, F. W., Science, 163, 75 (1969).

    Article  CAS  Google Scholar 

  42. Köhler, H., Shimizu, A., Paul, C., Moore, V., and Putnam, F. W., Nature, 227, 1318 (1970).

    Article  Google Scholar 

  43. Apella, E., Proc. US Nat. Acad. Sci. (in the press).

  44. Hill, R. L., Lebovitz, H. E., Fellows, R. E., and Delanay, R., Gamma Globulins, Structure and Control of Biosynthesis, Nobel Symp., 3 (edit. by Killander, J.), 109 (Almqvist and Wiksell, Stockholm, 1967).

    Google Scholar 

  45. Edelman, G. M., Biochemistry, 9, 3197 (1970).

    Article  CAS  Google Scholar 

  46. Atlas of Protein Sequence and Structure (edit. by Dayhoff, M. O.), 25 (National Biomedical Research Foundation, Silver Spring, 1969).

  47. Fruchter, R. G., Jackson, S. A., Mole, L. E., and Porter, R. R., Biochem. J., 116, 249 (1970).

    Article  CAS  Google Scholar 

  48. Pink, J. R. L., Buttery, S. H., Devries, G. M., and Milstein, C., Biochem. J., 117, 33 (1970).

    Article  CAS  Google Scholar 

  49. Gray, W. R., Dreyer, W. J., and Hood, L., Science, 155, 465 (1967).

    Article  CAS  Google Scholar 

  50. Hilschmann, N., Z. Physiol. Chem., 348, 1077 (1967).

    Article  CAS  Google Scholar 

  51. Putnam, F. W., Shinoda, T., Titani, K., and Wikler, M., Science, 157, 1050 (1967).

    Article  CAS  Google Scholar 

  52. Wang, A. C., Shuster, J., and Fudenberg, H. H., J. Mol. Biol., 41, 83 (1969).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Max Planck Institut für Experimentelle Medizin, Göttingen

    MAXIME HESS & NORBERT HILSCHMANN

  2. Centre Départemental de Transfusion Sanguine et de Génétique Humaine, Rouen-Bois-Guillaume

    LILIANE RIVAT, CLAUDE RIVAT & CLAUDE ROPARTZ

Authors
  1. MAXIME HESS
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  2. NORBERT HILSCHMANN
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  3. LILIANE RIVAT
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  4. CLAUDE RIVAT
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  5. CLAUDE ROPARTZ
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HESS, M., HILSCHMANN, N., RIVAT, L. et al. Isotypes in Human Immunoglobulin λ-Chains. Nature New Biology 234, 58–61 (1971). https://doi.org/10.1038/newbio234058a0

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