Abstract
A GROUP B herpesvirus is important in the aetiology of Marek's disease, a highly contagious lymphoproliferative disease of chickens1,2. Chicks inoculated with enveloped Marek's disease herpesvirus (MDHV), extracted from feather follicle epithelium of chickens with the disease, developed tumour-like aggregates of lymphoid cells in the viscera and frequently in the peripheral nerves3,4. Cultures of chicken embryo fibroblast (CEF) cells infected with MDHV develop discrete foci of altered cells5. Our data show that MDHV infection of cultures of CEF cells, previously infected with an avian leucosis virus (RAV-2), results in both a reduction in the number of MDHV foci and an increase in the complement fixing avian leucosis antigen (COFAL)6 titre.
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FRANKEL, J., GROUPÉ, V. Interactions between Marek's Disease Herpesvirus and Avian Leucosis Virus in Tissue Culture. Nature New Biology 234, 125–126 (1971). https://doi.org/10.1038/newbio234125a0
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DOI: https://doi.org/10.1038/newbio234125a0
