Abstract
RECENT progress in the definition of the DL-A antigens within a closely bred colony of beagles maintained at the Mary Imogene Basset Hospital (Cooperstown colony) has shown that these antigens are components of the principal system of histocompatibility (DL-A) in the dog1–3. Dausset and associates4 have described the segregation of DL-A antigens in 679 offspring of 151 consecutive matings within the Coopers-town colony. Through methods of backcross analysis, 23 DL-A haplotypes (that is, specificities determined by the DL-A region of one single chromosome) have been identified, and the DL-A genotypes of 1,302 offspring of 517 matings in this colony have been defined4. This combined genetic and serological information has provided an opportunity to reassess the reported survival rates of allogeneic bone marrow transplantation in serologically matched littermate dogs5. We describe here the long term survival of bone marrow transplants and renal allografts obtained from the same donors in nine littermate and three non-littermate recipients selected on the basis of genetic and serological criteria of DL-A compatibility in the Cooperstown colony. The results are contrasted with the survival of twenty-two renal allografts performed in untreated recipients selected on the basis of similar criteria.
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RAPAPORT, F., CANNON, F., BLUMENSTOCK, D. et al. Induction of Unresponsiveness to Canine Renal Allografts by Total Body Irradiation and Bone Marrow Transplantation. Nature New Biology 235, 190–192 (1972). https://doi.org/10.1038/newbio235190a0
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DOI: https://doi.org/10.1038/newbio235190a0
