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Synthesis of Haemoglobin Lepore

Abstract

HAEMOGLOBIN Lepore is a class of haemoglobin variants composed of α-chains and hybrids of δ and β-chains, which can be designated as α2(δβ)2. The N-terminal amino-acid sequence of the hybrid chains corresponds to that of δ-chains, while the C-terminal sequence corresponds to that of β-chains. A misplaced synapse of the δ and β gene loci is thought to have occurred during meiosis, followed by a non-homologous cross-over1. Three types are known which differ in the position of the cross-over: Hb Lepore Hollandia2,3, Hb Lepore Baltimore4, and Hb Lepore Boston (Washington)5,6.

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WHITE, J., LANG, A., LORKIN, P. et al. Synthesis of Haemoglobin Lepore. Nature New Biology 235, 208–210 (1972). https://doi.org/10.1038/newbio235208a0

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