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RNA of RNA Tumour Viruses contains Poly A

Nature New Biology volume 236, pages 227–231 (1972)Cite this article

Abstract

Molecular hybridization with radioactive polyuridylic acid has been used to detect regions of polyadenylic acid in virus RNA. On the average, RNA from tumour viruses is twenty-five to fifty-fold richer in polyadenylic acid than RNA from non-oncogenic viruses. Polyacrylamide gel electrophoresis permitted a qualitative distinction between RNA preparations from the two virus classes.

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References

  1. Hadjirassilious, A., and Brawerman, G., J. Mol. Biol., 20, 1 (1966).

    Article  Google Scholar 

  2. Edmonds, M., Vaughn, M. H., and Nakazato, H., Proc. US Nat. Acad. Sci., 68, 1336 (1971); Lee, Y. S., Mendecki, J., and Brawerman, G., ibid., 1331 (1971); Darnell, J. E., Wall, R., and Tushinski, R. J., ibid., 1321 (1971).

    Article  CAS  Google Scholar 

  3. Seeber, S., and Busch, H., J. Biol. Chem., 246, 7151 (1971).

    CAS  PubMed  Google Scholar 

  4. Handbook in Biochemistry (edit. by Sober, H. A.), H62 (Chemical Rubber Co., Cleveland, Ohio, 1968).

  5. Kates, J., Cold Spring Harbor Symp. Quant. Biol., 35, 743 (1970).

    Article  CAS  Google Scholar 

  6. Philipson, L., Wall, R., Glickman, G., and Darnell, J. E., Proc. US Nat. Acad. Sci., 68, 2806 (1971).

    Article  CAS  Google Scholar 

  7. Darnell, J. E., Philipson, L., Wall, R., and Adesnik, M., Science, 174, 507 (1971).

    Article  CAS  Google Scholar 

  8. Edmonds, M., and Abrams, R., J. Biol. Chem., 235, 1142 (1960).

    CAS  PubMed  Google Scholar 

  9. Temin, H. M., and Mizutani, S., Nature, 226, 1211 (1970); Baltimore, D., ibid., 1209 (1970); Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., ibid., 227, 563 (1970).

    Article  CAS  Google Scholar 

  10. Spiegelman, S., Burny, A., Das, M. R., Keydar, J., Schlom, J., Travnicek, M., and Watson, K., Nature, 228, 430 (1970).

    Article  CAS  Google Scholar 

  11. Baltimore, D., and Smoler, D., Proc. US Nat. Acad. Sci., 69, 1507 (1971); Goodman, N. C., and Spiegelman, S., ibid., 68, 2203 (1971); Wells, R., Biochemistry (in the press).

    Article  Google Scholar 

  12. Gallo, R. C., Nature, 234, 194 (1971).

    Article  CAS  Google Scholar 

  13. Duesberg, P., Helm, K. V. D., and Canaani, E., Proc. US Nat. Acad. Sci., 68, 2505 (1971).

    Article  CAS  Google Scholar 

  14. Darnell, J. E., Paman, S., and Baltimore, D., in Prospects in Virology, 4, 16 (edit. by Pollard, M.) (Harper and Row, New York, 1965).

    Google Scholar 

  15. Portner, A., and Kingsbury, D. W., Nature, 228, 1196 (1970).

    Article  CAS  Google Scholar 

  16. Armstrong, J., Edmonds, M., Nakazato, H., Philips, B., and Vaughan, M., Science (in the press).

  17. Bellamy, A. R., and Joklik, W. K., Proc. US Nat. Acad. Sci., 58, 1389 (1967); Shatkin, A. J., and Sipe, J. D., ibid., 59, 246 (1978).

    Article  CAS  Google Scholar 

  18. Schlom, J., and Spiegelman, S., Science, 174, 840 (1971).

    Article  CAS  Google Scholar 

  19. Chopra, H. C., and Mason, M. M., Cancer Res., 30, 2081 (1970).

    CAS  PubMed  Google Scholar 

  20. Schlom, J., and Spiegelman, S., Proc. US Nat. Acad. Sci., 68, 1613 (1971).

    Article  CAS  Google Scholar 

  21. Gallo, R. C., Yang, S. S., and Ting, R. C., Nature, 228, 927 (1970).

    Article  CAS  Google Scholar 

  22. Gallo, R. C., Blood, 39, 117 (1972).

    CAS  PubMed  Google Scholar 

  23. Tocchini-Valentini, G. P., and Crippa, M., in II Lepetit Colloquia on Biology and Medicine (edit. by Silvestri, C.) (North-Holland, Amsterdam, 1971).

    Google Scholar 

  24. Torelli, U. L., Torelli, G. M., Andreoli, A., and Mauri, C., Nature, 226, 1163 (1970).

    Article  CAS  Google Scholar 

  25. Axel, R., Schlom, J., and Spiegelman, S., Nature, 235, 32 (1971); Proc. US Nat. Acad. Sci. (in the press); Kufe, D., Hehlmann, R., and Spiegelman, S., Science, 175, 182 (1972).

    Article  Google Scholar 

  26. Attardi, G., and Amaldi, F., Ann. Rev. Biochem., 39, 183 (1970); several articles in Nature New Biology, 232, 48–56 (1971).

    Article  CAS  Google Scholar 

  27. Darnell, J. E., Bact. Revs. 32, 262 (1968).

    CAS  Google Scholar 

  28. Altaian, S., and Smith, J. D., Nature New Biology, 233, 35 (1971).

    Article  Google Scholar 

  29. Lindberg, U., and Darnell, J. E., Proc. US Nat. Acad. Sci., 65, 1089 (1970).

    Article  CAS  Google Scholar 

  30. Handbook in Biochemistry (edit. by Sober, H. A.), H52 (Chemical Rubber Co., Cleveland, Ohio, 1968).

  31. Britten, R. J., and Kohn, D. E., Science, 161, 529 (1968); Britten, R. J., and Davidson, E. H., ibid., 165, 349 (1969); Crick, F., Natare, 234, 25 (1971); Ohta, T., and Kimura, M., ibid., 233, 118 (1971).

    Article  CAS  Google Scholar 

  32. Huebner, R. J., and Todaro, G. J., Proc. US Nat. Acad. Sci., 64, 1087 (1969).

    Article  CAS  Google Scholar 

  33. Temin, H. M., J. Nat. Cancer Inst., 46, 111 (1971).

    Google Scholar 

Download references

Author information

Author notes

  1. SERGIO MARSHALL: On leave from Biology Department, Brandeis University, Waltham Massachusetts.

Authors and Affiliations

  1. Laboratory of Molecular Aging, Gerontology Research Center, NICHD, NIH, and Baltimore City Hospitals, Baltimore, Maryland, 21224

    DAVID GILLESPIE & SERGIO MARSHALL

  2. Laboratory of Tumor Cell Biology, National Cancer Institute, NIH, PHS, Department of Health, Education and Welfare, Bethesda, Maryland, 20014

    ROBERT C. GALLO

Authors
  1. DAVID GILLESPIE
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  2. SERGIO MARSHALL
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  3. ROBERT C. GALLO
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GILLESPIE, D., MARSHALL, S. & GALLO, R. RNA of RNA Tumour Viruses contains Poly A. Nature New Biology 236, 227–231 (1972). https://doi.org/10.1038/newbio236227a0

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  • DOI: https://doi.org/10.1038/newbio236227a0

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