Abstract
IN addition to its well known antiviral activity, interferon has recently been shown to inhibit the multiplication of tumour and mammalian cells in cell culture1–6. We report here the inhibition by interferon of DNA synthesis induced in mouse spleen lymphocytes by the non-viral stimuli phytohaemagglutinin (PHA) and allogeneic lymphocytes. These findings are in accord with our contention that interferon affects cell function and, furthermore, they suggest that by acting on lymphocytes, interferon plays a role in the immunological response of the host.
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LINDAHL-MAGNUSSON, P., LEARY, P. & GRESSER, I. Interferon inhibits DNA Synthesis induced in Mouse Lymphocyte Suspensions by Phytohaemagglutinin or by Allogeneic Cells. Nature New Biology 237, 120–121 (1972). https://doi.org/10.1038/newbio237120a0
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DOI: https://doi.org/10.1038/newbio237120a0
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