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Stimulation by Dibutyryl Cyclic AMP of Serotonin Synthesis and Tryptophan Transport in Brain Slices

Nature New Biology volume 237, pages 245–247 (1972)Cite this article

Abstract

N6,O2-′Dibutyryl cyclic AMP (dibutyryl cyclic AMP), a derivative of 3′,5′-adenosine monophosphate (cyclic AMP) resistant to phosphodiesterase inactivation, has been reported to stimulate serotonin and melatonin synthesis in the pineal gland in vitro1–3. In brain adenyl cyclase and phosphodiesterase, which catalyse the formation and the inactivation of cyclic AMP, are found chiefly in the synaptosomal fraction of the tissue homogenates4, where vesicles containing monoamine are also present5. These factors prompted us to study the effects of cyclic AMP and its dibutyryl derivative on the synthesis of brain monoamines.

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Authors and Affiliations

  1. Department of Pharmacology and Therapy, School of Medicine, Barcelona

    J. FORN

  2. Institute of Pharmacology, University of Cagliari,

    A. TAGLIAMONTE, P. TAGLIAMONTE & G. L. GESSA

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  1. J. FORN
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  2. A. TAGLIAMONTE
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  3. P. TAGLIAMONTE
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  4. G. L. GESSA
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FORN, J., TAGLIAMONTE, A., TAGLIAMONTE, P. et al. Stimulation by Dibutyryl Cyclic AMP of Serotonin Synthesis and Tryptophan Transport in Brain Slices. Nature New Biology 237, 245–247 (1972). https://doi.org/10.1038/newbio237245a0

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