Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Changes in Fluid Intake suggesting Depressed Appetites in Rats with Central Catecholaminergic Lesions

Nature New Biology volume 237, pages 279–281 (1972)Cite this article

Abstract

THE catecholaminergic neurones of the mammalian brain are generally believed to be important in the control of voluntary behaviour and affect. The evidence for this comes from work with pharmacological agents which enhance or block the post-synaptic effects of noradrenergic or dopaminergic neurones1–3. This has led to speculations implicating central catecholaminergic dysfunction in affective disorders such as depression1,4,5 and in other disorders such as Parkinson's disease6 and schizophrenia7,8. But research on the behavioural effects in animals of pharmacological interference with the normal functions of central catecholamines has been hindered by the fact that the sudden withdrawal of either noradrenaline or dopamine leads to behavioural sedation and inactivity9–14, which precludes any fine analysis of behavioural deficits.

This is a preview of subscription content, access via your institution

Access options

References

  1. Schildkraut, J. J., and Kety, S. S., Science, 156, 21 (1967).

    Article  CAS  Google Scholar 

  2. Anden, N. E., Carlsson, A., and Haggendal, J., Pharmacol. Rev., 9, 119 (1969).

    CAS  Google Scholar 

  3. Fuxe, K., Hokfelt, T., and Ungerstedt, U., Intern. Rev. Neurobiol., 13, 93 (1970).

    Article  CAS  Google Scholar 

  4. Stein, L., in Antidepressant Drugs (edit. by Garattini, S., and Dukes, M. N. G.), 130 (Excerpta Medica Foundation, Amsterdam, 1967).

    Google Scholar 

  5. Schildkraut, J. J., in Biochemistry, Schizophrenias and Affective Illnesses (edit. by Himwich, H.), 198 (Williams and Wilkins, Baltimore, 1970).

    Google Scholar 

  6. Hornykiewicz, O., Pharmacol. Rev., 18, 925 (1966).

    CAS  PubMed  Google Scholar 

  7. Bourdillon, R. E., and Ridges, A. P., in Biochemistry, Schizophrenias and Affective Illnesses (edit. by Himwich, H.), 123 (Williams and Wilkins, Baltimore, 1970).

    Google Scholar 

  8. Stein, L., and Wise, C., Science, 171, 1032 (1971).

    Article  CAS  Google Scholar 

  9. Carlsson, A., Fuxe, K., and Hokfelt, T., J. Pharm. Pharmacol., 19, 481 (1967).

    Article  CAS  Google Scholar 

  10. Carlsson, A., Fuxe, K., Hokfelt, T., and Lindqvist, M., J. Pharm. Pharmacol., 18, 60 (1966).

    Article  CAS  Google Scholar 

  11. Goldstein, M., and Nakajima, K., J. Pharm. Exp. Ther., 157, 96 (1967).

    CAS  Google Scholar 

  12. Corrodi, H., Fuxe, K., Ljungdahl, A., and Ogren, S.-O., Brain Res., 24, 451 (1970).

    Article  CAS  Google Scholar 

  13. Svensson, H., and Waldeck, B., Europ. J. Pharmacol., 7, 278 (1969).

    Article  CAS  Google Scholar 

  14. Ungerstedt, U., Acta Physiol. Scand., Suppl. 367, 95 (1971).

  15. Bloom, F. S., Algeri, S., Groppetti, A., Revueita, E., and Costa, E., Science, 166, 1284 (1969).

    Article  CAS  Google Scholar 

  16. Uretsky, N. J., and Iversen, L. L., J. Neurochem., 17, 269 (1970).

    Article  CAS  Google Scholar 

  17. Breese, G. R., and Traylor, T. D., J. Pharm. Exp. Ther., 174, 413 (1970).

    CAS  Google Scholar 

  18. Ungerstedt, U., Europ. J. Pharmacol., 5, 107 (1968).

    Article  CAS  Google Scholar 

  19. Uretsky, N. J., and Iversen, L. L., Nature, 221, 557 (1969).

    Article  CAS  Google Scholar 

  20. Simmonds, M. A., and Uretsky, N. J., Brit. J. Pharmacol., 40, 564P (1970).

    Article  CAS  Google Scholar 

  21. Merlis, J. K., Amer. J. Physiol., 131, 67 (1940).

    Article  CAS  Google Scholar 

  22. Fleming, R. M., Clark, W. G., Fenster, E. D., and Towne, J. C., Anal. Chem., 37, 692 (1965).

    Article  CAS  Google Scholar 

  23. Katzman, R., Bjorklund, A., Owman, C., Stenevi, U., and West, K., Brain Res., 25, 579 (1971).

    Article  CAS  Google Scholar 

  24. Ungerstedt, U., in 6-Hydroxydopamine and Catecholamine Neurons (edit. by Malmfors, T., and Thoenen, H.), 101 (North-Holland, Amsterdam, 1971).

    Google Scholar 

  25. Wise, C. D., and Stein, L., Science, 163, 299 (1969).

    Article  CAS  Google Scholar 

  26. Stein, L., and Wise, C. D., J. Comp. Physiol. Psychol., 67, 189 (1969).

    Article  CAS  Google Scholar 

  27. Beck, A. T., Depression, 33 (Harper and Row, New York, 1967).

  28. Schildkraut, J. J., Amer. J. Psychiat., 122, 509 (1965).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychiatry, Yale University, New Haven, Connecticut, 06508

    C. A. SORENSON

  2. Department of Psychology, University of California, Los Angeles

    GAYLORD D. ELLISON

  3. Veterans Administration Hospital, Sepulveda, California

    DAVID MASUOKA

Authors
  1. C. A. SORENSON
    View author publications

    Search author on:PubMed Google Scholar

  2. GAYLORD D. ELLISON
    View author publications

    Search author on:PubMed Google Scholar

  3. DAVID MASUOKA
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SORENSON, C., ELLISON, G. & MASUOKA, D. Changes in Fluid Intake suggesting Depressed Appetites in Rats with Central Catecholaminergic Lesions. Nature New Biology 237, 279–281 (1972). https://doi.org/10.1038/newbio237279a0

Download citation

  • Received:

  • Revised:

  • Issue date:

  • DOI: https://doi.org/10.1038/newbio237279a0

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing