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Inhibition of Minicircular DNA Replication in Escherichia coli 15 by Rifampicin

Nature New Biology volume 238, pages 202–203 (1972)Cite this article

Abstract

RECENT evidence supports a direct involvement of transcription in the DNA replication of E. coli1,2, phage λ3, and phage M 134,5. Transcription of the replication origin appears to be essential for the initiation of a new round of DNA replication. However, all the systems mentioned have particular disadvantages; for example, DNA replication in these systems also requires protein synthesis, and since a transcriptional block also inhibits protein synthesis, setting up experiments and interpretation of data can be difficult.

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Authors and Affiliations

  1. Max-Planck-Institut für Biochemie, 8033, Martinsried bei, München

    J. MESSING, W. L. STAUDENBAUER & P. H. HOFSCHNEIDER

Authors
  1. J. MESSING
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  2. W. L. STAUDENBAUER
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  3. P. H. HOFSCHNEIDER
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MESSING, J., STAUDENBAUER, W. & HOFSCHNEIDER, P. Inhibition of Minicircular DNA Replication in Escherichia coli 15 by Rifampicin. Nature New Biology 238, 202–203 (1972). https://doi.org/10.1038/newbio238202a0

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  • DOI: https://doi.org/10.1038/newbio238202a0

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