Abstract
Experiments on head grafting and regeneration in Hydra have been used to show quantitatively that diffusion of a morphogen is a plausible basis for the control of differentiation.
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Wolpert, L., J. Theoret. Biol., 25, 1 (1969).
Wolpert, L., Adv. Morphogenesis, 6, 183 (1971).
Crick, F. H. C., Symp. Soc. Exp. Biol., 25, 429 (1971).
Goodwin, B., & Cohen, M. H., J. Theoret. Biol., 25, 49 (1969).
Cohen, M. H., Symp. Soc. Exp. Biol., 25, 455 (1971).
Crick, F. H. C., Nature, 225, 420 (1970).
Cohen, M. H., & Robertson, A., J. Theoret. Biol, 31, 101 (1971).
Webster, G., Biol. Rev., 46, 1 (1971).
Wolpert, L., Hicklin, J., & Hornbruch, A., Symp. Soc. Exp. Biol., 25, 391 (1971).
Wilby, O. K., & Webster, G., J. Embryol. Exp. Morphol, 24, 595 (1970).
Crank, J., The Mathematics of Diffusion (Clarendon Press, Oxford, 1956).
Wolpert, L., Symp. Soc. Gen. Microbiol., 15, 270 (1965).
Lawrence, P., Crick, F. H. C., & Munro, M., J. Cell Sci. (in the press).
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WOLPERT, L., CLARKE, M. & HORNBRUCH, A. Positional Signalling along Hydra. Nature New Biology 239, 101–105 (1972). https://doi.org/10.1038/newbio239101a0
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DOI: https://doi.org/10.1038/newbio239101a0
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