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Control of Phenotypic Expresssion of Cultured Melanoma Cells by Melanocyte Stimulating Hormones

Nature New Biology volume 241, pages 213–215 (1973)Cite this article

Abstract

STUDIES of the mechanism through which MSH acts in mammals have been restricted to intact animals or to melanomas grown in animals1,2. We describe here a mouse melanoma cell line cultivated in monolayer which when exposed to MSH shows large increases in tyrosinase activity and melanin content, as well as changes in growth characteristics and cellular morphology. In addition, we have found that adenosine 3',5'-monophosphate (cyclic AMP) or its analogue N6,O2'-dibutyryl cyclic AMP (diB cyclic AMP) will substitute for MSH, supporting previous evidence that MSH probably acts through cyclic AMP in mammals1,3.

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References

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Authors and Affiliations

  1. Department of Molecular Biophysics and Biochemistry and Departments of Dermatology and Anatomy, Yale University School of Medicine, New Haven, Connecticut, 06510

    GLENDA WONG & J. PAWELEK

Authors
  1. GLENDA WONG
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  2. J. PAWELEK
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WONG, G., PAWELEK, J. Control of Phenotypic Expresssion of Cultured Melanoma Cells by Melanocyte Stimulating Hormones. Nature New Biology 241, 213–215 (1973). https://doi.org/10.1038/newbio241213a0

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