Abstract
VIMINOL, or 1-[α-(N-o-chlorobenzyl)-pyrryl]-2-di-sec-butylarnine ethanol p-hydroxybenzoate, has been identified as a centrally acting analgesic out of a large series of pyrrole derivatives1. The analgesic activity of the compound, studied as the race-mate, has been established by appropriate pharmacological methods and found to be independent from anti-inflammatory properties2. The animals treated with viminol show an obvious Straub phenomenon and after repeated parenteral administration they exhibit cross tolerance to morphine.
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References
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BELLA, D., FERRARI, V., FRIGENI, V. et al. Agonistic and Antagonistic Properties of Diastereoisomers in a New Central Analgesic. Nature New Biology 241, 282–284 (1973). https://doi.org/10.1038/newbio241282a0
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DOI: https://doi.org/10.1038/newbio241282a0
