Abstract
HAEMOGLOBIN P has been found amongst Nilotic populations of the then Belgian Congo, now called Zaire1,2 (Hb P Congo), and in the USA (Hb P Galveston)3. The abnormality in Hb P Galveston has been identified as β117 G19 His→Arg3, but the abnormality in Hb P Congo seems to be more complex and it has been suggested by Lehmann and Charlesworth4 that it is a “reversed Lepore” haemoglobin with a hybrid β-δ chain. In an extensive family study Dherte, Lehmann and Vandepitte1 found one man who had inherited Hbs A, S and P. His wife was a normal A/A homozygote and their children were all either A/S or A/P heterozygotes. Hybridization experiments demonstrated that the abnormality in the Hb P Congo was not in the α chain5. As the genes for the βA and βS chains are alleles at a single locus it is impossible for one individual to inherit Hbs A, S and P unless the gene for the non-α chain of Hb P is at a separate locus. A new genetic locus for a hybrid β-δ chain might be generated as shown in Fig. 1, by unequal but homologous crossing over of the genes for the δ and β chains6. One of the products of a crossing over would be a hybrid δ-β gene which would give rise to Hb Lepore. The other product would contain the genes for the δ and β chain and for a hybrid β-δ chain. The existence of homozygotes for Hb Lepore7 who make no Hb A or A2 suggests that the δ and β genes are in the order shown in Fig. 1. If a homozygote for the β-δ gene existed he would be expected to make Hb A and A2 as well.
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References
Dherte, P., Lehmann, H., and Vandepitte, J., Nature, 184, 1133 (1959).
Lambotte-Legrand, J. D. C., Ager, J. A. M., and Lehmann, H., J. Rev. Haemat., 15, 10 (1960).
Schneider, R. G., Alperin, J. B., Brimhall, B., and Jones, R. T., J. Lab. Clin. Med., 73, 616 (1969).
Lehmann, H., and Charlesworth, D., Biochem. J., 119, 42P (1970).
Gammack, D. B., Huehns, E. R., Lehmann, H., and Shooter, E. M., Acta Genet. Statist. Med., 11, 1 (1961).
Smithies, O., Cold Spring Harbor Symp. Quant. Biol., 29, 309 (1964).
Fessas, Ph., Stamatoyannopoulos, G., and Karaklis, A., Blood, 19, 1 (1962).
Barnabas, J., and Muller, C. J., Nature, 194, 931 (1962).
Curtain, C. C., Australian J. Exp. Biol., 42, 89 (1964).
Ostertag, W., and Smith, E. W., European J. Biochem., 10, 371 (1969).
Baglioni, C., and Ventruto, V., European J. Biochem., 5, 29 (1969).
Labie, D., Schroeder, W. A., and Huisman, T. H. J., Biochim. Biophys. Acta, 127, 428 (1966).
Huisman, T. M. J., and Dozy, A. M., J. Chromatog., 19, 160 (1965).
Yanase, T., Hamada, M., Seita, M., Ohya, I., Ohta, Y., Imamura, T., Fujimura, T., Kawasaki, K., and Yamaoka, K., Jap. J. Hum. Genetics, 13, 40 (1968).
Ohta, Y., Yamaoka, K., Sumida, I., and Yanase, T., Nature New Biology, 234, 218 (1971).
Imai, K., Morimoto, H., Kotani, M., Watari, M., Hirata, W., and Kuroda, M., Biochim. Biophys. Acta, 200, 189 (1970).
Clegg, J. B., Naughton, M. A., and Weatherall, D. J., J. Mol. Biol.,19, 91 (1966).
Kilmartin, J. V., and Rossi-Bernardi, L., Biochem. J., 124, 31 (1970).
Winslow, R. M., and Ingram, V. M., J. Biol. Chem., 241, 1144 (1966).
White, J. M., Lang, A., Lorkin, P. A., Lehmann, H., and Reeve, J., Nature New Biology, 235, 208 (1972).
Beale, D., Biochem. J., 103, 129 (1967).
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BADR, F., LORKIN, P. & LEHMANN, H. Haemoglobin P-Nilotic containing a β-δ Chain. Nature New Biology 242, 107–110 (1973). https://doi.org/10.1038/newbio242107a0
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DOI: https://doi.org/10.1038/newbio242107a0
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