Abstract
SUSCEPTIBILITY to the spontaneous development of tumours is strain-dependent in mice1. Genetic factors are undoubtedly involved. Mintz et al.2 used tetraparental chimaeras derived from ovum fusion to investigate the effect on tumour development of combinations of strains which differ in susceptibility I and reported that the incidence of specific tumours in chim-aeras is concordant with that of mice of the more susceptible strain. We have found, on the contrary, delayed onset or absence of lymphomas in a small group of AKR↔CBA-T6T6/H chimaeras3. The AKR strain is notable for the early onset and almost total incidence of thymic lyphoma4. We now report confirmatory observations on a larger number of animals.
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References
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BARNES, R., TUFFREY, M. & Ford, C. Suppression of Lymphoma Development in Tetraparental AKR Mouse Chimaeras derived from Ovum Fusion. Nature New Biology 244, 282–284 (1973). https://doi.org/10.1038/newbio244282a0
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DOI: https://doi.org/10.1038/newbio244282a0
