Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Variations among Sublines of Inbred AKR Mice

Abstract

THE AKR inbred line of mice, developed as a strain with a high incidence of leukaemia, has found wide use in the fields of genetics, immunology, virology, and cancer research. While a certain degree of variability is expected among sublines derived from any inbred strain, rather striking differences have been observed among AKR sublines. Because such differences can be crucial to the usefulness of AKR mice for biomedical research, observations regarding some of these AKR sublines have been collected from several laboratories.

This is a preview of subscription content, access via your institution

Access options

References

  1. Staats, J., Cancer Res., 32, 1609 (1972).

    CAS  PubMed  Google Scholar 

  2. Reif, A. E., and Allen, J. M. V., J. exp. Med., 120, 413 (1964).

    Article  CAS  Google Scholar 

  3. Boyse, E. A., Itakura, K., Stockert, E., Iritani, C. A., and Miura, M., Transplantation, 11, 351 (1971).

    Article  CAS  Google Scholar 

  4. Klein, J., and Shreffler, D. C., Transplantation Rev., 6, 3 (1971).

    CAS  Google Scholar 

  5. Boyse, E. A., Stockert, E., and Old, L. J., in International Convocation on Immunology (edit, by Rose, N. R., and Milgrom, F.) 353 (Karger, Basel, 1969).

    Google Scholar 

  6. Stockert, E., Old, L. J., and Boyse, E. A., J. exp. Med., 133, 1334 (1971).

    Article  CAS  Google Scholar 

  7. Snell, G. D., and Cherry, M., in RNA Viruses and Host Genome in Oncogenesis (edit, by Emmelot, P., and Bentvelzen, P.) 221 (North-Holland, Amsterdam, 1971).

    Google Scholar 

  8. Schlesinger, M., and Hurvitz, D., Transplantation, 7, 132 (1969).

    Article  CAS  Google Scholar 

  9. Itakura, K., Hutton, J. J., Boyse, E. A., and Old, L. J., Transplantation, 13, 239 (1972).

    Article  CAS  Google Scholar 

  10. Blakenhorn, E. P., and Douglas, T. C., J. Hered., 63, 259 (1972).

    Article  Google Scholar 

  11. Hilgers, J., Nowinski, R. C., Geering, G., and Hardy, W., Cancer Res., 32, 98 (1972).

    CAS  PubMed  Google Scholar 

  12. Hilgers, J., thesis Mondeel Univ. (1972).

  13. Hilgers, J., and Galesloot, J., Intern. J. Cancer (in the press).

  14. Lilly, F., J. natn. Cancer Inst., 45, 163 (1970).

    CAS  Google Scholar 

  15. John, M., Carswell, E., Boyse, E. A., and Alexander, G., Nature new Biol., 238, 57 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ACTON, R., BLANKENHORN, E., DOUGLAS, T. et al. Variations among Sublines of Inbred AKR Mice. Nature New Biology 245, 8–10 (1973). https://doi.org/10.1038/newbio245008a0

Download citation

  • Received:

  • Issue date:

  • DOI: https://doi.org/10.1038/newbio245008a0

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing