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Alkaline Phosphatase in Vascular Smooth Muscle

Nature New Biology volume 245, pages 53–55 (1973)Cite this article

Abstract

THE free calcium ion is the essential common requirement for all muscle contraction including that of the vascular smooth muscle1,2. Tension development by the contractile proteins is a direct function of the Ca2+ concentration to which they are exposed. A mechanism by which the levels of activator calcium may be regulated in vascular smooth muscle is provided by the recent demonstration in the aortic microsomal fraction of a “pump” actively sequestering Ca2+ (ref. 3). Any conditions affecting this “pump” will also modify intracellular calcium levels and, consequently, tension development.

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Authors and Affiliations

  1. Section of Hypertension and Clinical Hemodynamics, Veterans Administration Hospital, Washington DC, 20422

    CONSTANTINOS J. LIMAS & JAY N. COHN

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  1. CONSTANTINOS J. LIMAS
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  2. JAY N. COHN
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LIMAS, C., COHN, J. Alkaline Phosphatase in Vascular Smooth Muscle. Nature New Biology 245, 53–55 (1973). https://doi.org/10.1038/newbio245053a0

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