Abstract
THERE is ample evidence to suggest that visual receptor rhodopsin consists of 11-cis-retinal linked through a Schiff base to the protein opsin1–4. When exposed to light, rhodopsin is converted to opsin and all-trans-retinal. The replenishment of rhodopsin in vivo requires an isomerisation system which converts all-trans-retinal to 11-cis retinal (see equation (3), scheme 1); the reaction of the latter with opsin to form rhodopsin is known to occur at a facile rate5.
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AMER, S., AKHTAR, M. Studies on the Regeneration of Rhodopsin from All-Trans-Retinal in Isolated Rat Retinae. Nature New Biology 245, 221–223 (1973). https://doi.org/10.1038/newbio245221a0
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DOI: https://doi.org/10.1038/newbio245221a0
