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Differential Inhibition of Catabolite-sensitive Enzyme Induction by Intercalating Dyes

Nature New Biology volume 245, pages 257–260 (1973)Cite this article

Abstract

Differential inhibition by intercalating dyes of catabolite-sensitive enzyme induction is reversed by cyclic AMP and could be due to in vivo differences in DNA conformation which increase the accessibility of the promoter region for dye binding and thus selectively inhibit transcription.

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References

  1. Hurwitz, C., and Rosano, C. L., Biochim. biophys. Acta, 108, 697 (1965).

    Article  CAS  Google Scholar 

  2. Borst, P., A. Rev. Biochem., 41, 333 (1972).

    Article  CAS  Google Scholar 

  3. Hirota, Y., Proc. natn. Acad. Sci., U.S.A., 46, 57 (1960).

    Article  CAS  Google Scholar 

  4. Watanabe, T., and Fukasawa, T., J. Bact., 81, 679 (1961).

    CAS  PubMed  Google Scholar 

  5. Rao, M. M., Rebello, P. F., and Pogell, B. M., J. biol. Chem., 244, 112 (1969).

    CAS  PubMed  Google Scholar 

  6. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265 (1951).

    CAS  PubMed  Google Scholar 

  7. Sankaran, L., and Pogell, B. M., Analyt. Biochem., 54, 146 (1973).

    Article  CAS  Google Scholar 

  8. Okanishi, M., Ohta, T., and Umezawa, H., J. Antibiot., Tokyo, 23, 45 (1970).

    Article  CAS  Google Scholar 

  9. Gallo, M., and Katz, E., J. Bact., 109, 659 (1972).

    CAS  PubMed  Google Scholar 

  10. Kornberg, H. L., and Gotto, A. M., Biochem. J., 78, 69 (1961).

    Article  CAS  Google Scholar 

  11. Pardee, A. B., Jacob, F., and Monod, J., J. molec. Biol., 1, 165 (1959).

    Article  CAS  Google Scholar 

  12. Eron, L., and Block, R., Proc. natn. Acad. Sci. U.S.A., 68, 1828 (1971).

    Article  CAS  Google Scholar 

  13. Conde, F., Del Campo, F. F., and Ramirez, J. M., FEBS Lett., 16, 156 (1971).

    Article  CAS  Google Scholar 

  14. Perlman, R., and Pastan, I., Biochem. biophys. Res. Commun., 30, 656 (1968).

    Article  CAS  Google Scholar 

  15. Buettner, M. J., Spitz, E., and Rickenberg, H. V., J. Bact., 114, 1068 (1973).

    CAS  PubMed  Google Scholar 

  16. Arditti, R. R., Scaife, J. G., and Beckwith, J. R., J. molec. Biol., 38, 421 (1968).

    Article  CAS  Google Scholar 

  17. Silverstone, A. E., Arditti, R. R., and Magasanik, B., Proc. natn. Acad. Sci. U.S.A., 66, 773 (1970).

    Article  CAS  Google Scholar 

  18. Arditti, R., Grodzicker, T., and Beckwith, J., J. Bact., 114, 652 (1973).

    CAS  PubMed  Google Scholar 

  19. Bilezikian, J. P., Kaempfer, R. O. R., and Magasanik, B., J. molec. Biol., 27, 495 (1967).

    Article  CAS  Google Scholar 

  20. Gotto, A. M., and Pogell, B. M., Biochem. biophys. Res. Commun., 9, 381 (1962).

    Article  CAS  Google Scholar 

  21. Pogell, B. M., Maity, B. R., Frumkin, S., and Shapiro, S., Archs. Biochem. Biophys., 116, 406 (1966).

    Article  CAS  Google Scholar 

  22. Torriani, A., Biochim. biophys. Acta, 38, 460 (1960).

    Article  CAS  Google Scholar 

  23. Schlesinger, M. J., and Levinthal, C., J. molec. Biol., 7, 1 (1963).

    Article  CAS  Google Scholar 

  24. Echols, H., Garen, A., Garen, S., and Torriani, A., J. molec. Biol., 3, 425 (1961).

    Article  CAS  Google Scholar 

  25. Waring, M. J., Nature, 219, 1320 (1968).

    Article  CAS  Google Scholar 

  26. Caspersson, T., Farber, S., Foley, G. E., Kudynowski, J., Modest, E. J., Simonsson, E., Wager, U., and Zech, L., Expl Cell Res., 49, 219 (1968).

    Article  CAS  Google Scholar 

  27. Weisblum, B., and De Haseth, P. L., Proc. natn. Acad. Sci., U.S.A., 69, 629 (1972).

    Article  CAS  Google Scholar 

  28. Pohl, F. M., Jovin, T. M., Baehr, W., and Holbrook, J. J., Proc. natn. Acad. Sci. U.S.A., 69, 3805 (1972).

    Article  CAS  Google Scholar 

  29. Worcel, A., and Burgi, E., J. molec. Biol., 71, 127 (1972).

    Article  CAS  Google Scholar 

  30. Travers, A., Baillie, D. L., and Pedersen, S., Nature new Biol., 243, 101 (1973).

    Article  Google Scholar 

  31. Pastan, I., and Perlman, R. L., J. biol. Chem., 244, 2226 (1969).

    CAS  PubMed  Google Scholar 

  32. Aboud, M., and Burger, M., Biochem. biophys. Res. Commun., 38, 1023 (1970).

    Article  CAS  Google Scholar 

  33. Jacquet, M., and Kepes, A., Biochem. biophys. Res. Commun., 36, 84 (1969).

    Article  CAS  Google Scholar 

  34. Silverstone, A. E., and Magasanik, B., J. Bact., 112, 1184 (1972).

    CAS  PubMed  Google Scholar 

  35. Wiens, A. W., and Moscona, A. A., Proc. natn. Acad. Sci., U.S.A., 69, 1504 (1972).

    Article  CAS  Google Scholar 

  36. von Hippel, P. H., and McGhee, J. D., A. Rev. Biochem., 41, 231 (1972).

    Article  CAS  Google Scholar 

  37. Clowes, R. C., Bact. Rev., 36, 361 (1972).

    CAS  PubMed  Google Scholar 

  38. Radloff, R., Bauer, W., and Vinograd, J., Proc. natn. Acad. Sci. U.S.A., 57, 1514 (1967).

    Article  CAS  Google Scholar 

  39. Wickner, W., Brutlag, D., Schekman, R., and Kornberg, A., Proc. natn. Acad. Sci. U.S.A., 69, 965 (1972).

    Article  CAS  Google Scholar 

  40. Sugino, A., Hirose, S., and Okazaki, R., Proc. natn. Acad. Sci. U.S.A., 69, 1863 (1972).

    Article  CAS  Google Scholar 

  41. Clewell, D. B., and Evenchik, B. G., J. molec. Biol., 75, 503 (1973).

    Article  CAS  Google Scholar 

  42. Riva, S., Fietta, A., Berti, M., Silvestri, L. G., and Romero, E., Antimicrob. Ag. Chemother., 3, 456 (1973).

    Article  CAS  Google Scholar 

  43. Cuzin, F., and Jacob, F., Annls Inst. Pasteur, 111, 427 (1966).

    CAS  Google Scholar 

  44. Arai, T., and Watanabe, T., Genet. Res., 10, 241 (1967).

    Article  CAS  Google Scholar 

  45. Nishimura, Y., Caro, L., Berg, C. M., and Hirota, Y., J. molec. Biol., 55, 441 (1971).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Microbiology, St Louis University School of Medicine, St Louis, Missouri, 63104

    L. SANKARAN & BURTON M. POGELL

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  1. L. SANKARAN
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  2. BURTON M. POGELL
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SANKARAN, L., POGELL, B. Differential Inhibition of Catabolite-sensitive Enzyme Induction by Intercalating Dyes. Nature New Biology 245, 257–260 (1973). https://doi.org/10.1038/newbio245257a0

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  • DOI: https://doi.org/10.1038/newbio245257a0

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