Abstract
The cell-mediated immune response following grafting of allogeneic tissue is characterised by the development of cytolytically active, thymus-derived (T) lymphocytes, which are involved in the destruction of grafted tissue. These effector T cells also destroy homologous alloantigen-bearing (‘target’) cells in vitro. The specificity of the lytic process is exquisite; only cells of the graft donor or of a related strain or individual are destroyed1, 2. The precise nature of the alloantigens against which the lymphocytes act remains, however, unknown.
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EDIDIN, M., HENNEY, C. The Effect of Capping H-2 Antigens on the Susceptibility of Target Cells to Humoral and T Cell-mediated Lysis. Nature New Biology 246, 47–49 (1973). https://doi.org/10.1038/newbio246047a0
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DOI: https://doi.org/10.1038/newbio246047a0
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