Abstract
MATURE B lymphocytes and plasma cells synthesise and secrete immunoglobulin antibodies restricted as to class, light chain type, allotype, idiotype, and specificity1 in accordance with the predictions of the clonal selection theory2. Membrane-associated immunoglobulin displayed on the surfaces of lymphocytes is also of a single class, light chain type and allotype3, 4, and is monospecific with respect to antibody combining sites5.
This is a preview of subscription content, access via your institution
Access options
References
Mäkelä, O., and Gross, A. M., Progr. Allergy, 14, 154 (1970).
Burnet, F. M., The Clonal Selection Theory of Acquired Immunity (Vanderbilt University Press, Nashville, 1959).
Litwin, S. D., J. Immun., 108, 1129 (1972).
Froland, S. S., and Natvig, J. B., J. exp. Med., 136, 409 (1972).
Raff, M. C., Feldmann, M., and DePetris, S., J. exp. Med., 136, 1024 (1973).
Finegold, I., Fahey, J., Manaker, R., and Rabson, A., Science, N. Y., 152, 1257 (1960).
Shevach, E. M., Herbeman, R., Frank, M. M., and Green, I., J. din. Invest., 51, 1933 (1972).
Bloom, A. D., Choi, K. W., and Lamb, B. J., Science, N.Y., 172, 382 (1972).
Takahashi, M., Takagi, N., Yagi, Y., Moore, G. E., and Pressman, D., Immunology, 102, 1388 (1969).
Hütteroth, T. H., Litwin, S. D., and Cleve, H., Cell. Immun., 5, 446 (1972).
Hütteroth, T. H., Cleve, H., and Litwin, S. D., J. Immun., 110, 1325 (1973).
Rabellino, E., Colon, S., Grey, H. M., and Unanue, E., J. exp. Med., 133, 156 (1971).
Hunter, W. M., and Greenwood, F. C., Nature, 194, 495 (1962).
Takahashi, T., Old, L., McIntire, R., and Boyce, E., J. exp. Med., 134, 815 (1971).
Shortman, K., Williams, N., and Adams, P., J. Immun. Meth., 1, 23 (1972).
Sell, S., Transplantn. Rev., 5, 19 (1970).
Greaves, M. F., Transplantn. Rev., 5, 45 (1970).
Anderson, H. R., Eur. J. Immun., 2, 11 (1972).
Bona, C. A., Trebiciavsky, L., Anteunis, A., Heucclin, C., and Robineaux, R., Eur. J. Immun., 2, 434 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LITWIN, S., LIN, P., HÜTTEROTH, T. et al. Multiple Heavy Chain Classes and Light Chain Types on Surfaces of Cultured Human Lymphoid Cells. Nature New Biology 246, 179–181 (1973). https://doi.org/10.1038/newbio246179a0
Received:
Revised:
Issue date:
DOI: https://doi.org/10.1038/newbio246179a0
This article is cited by
-
IgD on cell membranes of human lymphoid cell lines with multiple immunoglobulin classes
Nature (1974)
-
Criteria for the differentiation of lymphoid cell lines
Blut Zeitschrift für die Gesamte Blutforschung (1974)
