Figure 1: Synteny between filarial worms and C. elegans.

(a) Gene distribution on the C. elegans genome. Vertical bars represent the six C. elegans chromosomes (labeled at the bottom). Horizontal boxes within each bar indicate the location and strand of C. elegans genes (boxes on the left indicate the plus strand, and boxes on the right indicate the minus strand). (b) Gene distribution on the 12 longest L. loa scaffolds. Scaffolds are represented by horizontal bars and identified by labels on the left. Vertical colored boxes indicate the position and strand of each gene (boxes on the top indicate the plus strand, and boxes on the bottom indicate the minus strand). The color coding indicates the chromosome on which each ortholog in C. elegans is located and is consistent with the colors used in a. Gray boxes represent either genes without orthologs in C. elegans or genes with two or more homologs in distinct C. elegans chromosomes. (c) Distribution of L. loa (Ll) scaffold 4 orthologs on the C. elegans chromosome 3 (Ce III), W. bancrofti (Wb) and B. malayi (Bm) genomes. The scaffolds and chromosomes with the best matches to L. loa scaffold 4 on the basis of whole-genome alignment are shown. Each row contains one or more horizontal bars representing either chromosomes (C. elegans) or scaffolds (L. loa, B. malayi and W. bancrofti) from each sequenced genome. Purple boxes indicate the position and strand of the genes. Gray projections connect orthologous genes across organisms.